苹果淫院

Updated: Tue, 10/08/2024 - 20:06

On Wed, Oct. 9, campus is open to 苹果淫院 students, employees and essential visitors. Most classes are in-person. See Campus Public Safety website for details.


Le mercredi 9 octobre, le campus est accessible aux 茅tudiants et au personnel de l鈥橴niversit茅, ainsi qu鈥檃ux visiteurs essentiels. La plupart des cours ont lieu en pr茅sentiel. Voir le site Web de la Direction de la protection et de la pr茅vention pour plus de d茅tails.

Event

Online Seminar - Neuroimmune Interactions Shaping Social Behavior

Friday, April 30, 2021 11:00to12:00

The beneficial effects of infection and the ensuing inflammation on neurological disorders have previously been noted. For example, a subset of children with autism spectrum disorder (ASD) exhibits temporary but considerable improvements in their behavioral symptoms during episodes of fever, a sign of systemic inflammation. However, a mechanistic understanding of how fever-associated immune responses translate into behavioral relief鈥攂oth at the molecular and neural level鈥攊s lacking. We show that the social behavioral deficits in offspring exposed to maternal immune activation can be temporarily rescued by the inflammatory response elicited by the administration of lipopolysaccharide (LPS). This behavioral rescue was accompanied by a reduction in neural activity in the primary somatosensory cortex dysgranular zone (S1DZ), the hyperactivity of which has previously been implicated in the manifestation of behavioral phenotypes associated with offspring exposed to MIA. We also show that both the behavioral rescue and the reduction in neural activity are mediated through the expression of IL-17 receptor subunit a (IL-17Ra) in the neurons of the S1DZ.

This seminar will be given online via Zoom. Details in attached poster.

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