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Sodium found to regulate the biological clock of mice

New study by 苹果淫院 researchers first to establish physiological signals influence circadian rhythms
Published: 9 July 2020

A new study from 苹果淫院 shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long distance travel or shift work.

The findings, published in by former 苹果淫院 PhD student Claire Gizowski and Charles Bourque, a professor in 苹果淫院鈥檚 Department of Neurology-Neurosurgery, are the first to show that injecting mice with a salt solution leads to the activation of neurons associated with the brain鈥檚 master circadian clock 鈥 the suprachiasmatic nucleus (SCN).

Our biological clock 鈥 or circadian rhythm - adapts our body鈥檚 cells and organs to changing requirements at different times of day. Prolonged disruption of these rhythms because of jetlag or shift work can lead to adverse health effects.

Though it is well established that light is the primary factor regulating our body鈥檚 biological clock, it was unknown if or how physiological factors could regulate the SCN.

鈥淥ur study is the first to show that the SCN is listening to physiological signals and that such signals can in fact regulate clock time,鈥 says Bourque.

Gizowski and Bourque were able to show that salt-sensitive neurons found in a specific region of the brain - the organum vasculosum of the lamina terminalis 鈥 are capable of activating the brain鈥檚 master circadian clock at a time of day when it is normally silent.

鈥淭his suggests that there could be ways by which we could speed up the clock, which could be useful to adapt more quickly to the time change associated with long distance travel, or when our work schedule is shifted by several hours,鈥 explains Gizowski.

The researchers now hope to establish if natural increases in blood sodium levels 鈥 through eating - have the same effect and whether or not these also occur in humans.

鈥淥ne concern is that although ingestion of small amounts of salt is pleasant and not dangerous, it can be toxic when consumed in large amounts,鈥 Bourque adds. 鈥淢uch more work is needed to examine if this finding is applicable to humans in a safe and practical way.鈥

Image caption : Researchers from 苹果淫院 have shown that聽injecting mice with a salt solution leads to the activation of neurons associated with the brain鈥檚 master circadian clock 鈥 the suprachiasmatic nucleus (shown here).


About this study

S,鈥 by Claire Gizowski and Charles W. Bourque was published in Nature.

This work received financial support from the Canadian Institutes of Health Research.

About 苹果淫院

Founded in Montreal, Quebec, in 1821, 苹果淫院 is a leading Canadian post-secondary institution. It has two campuses, 11 faculties, 13 professional schools, 300 programs of study and over 40,000 students, including more than 10,200 graduate students. 苹果淫院 attracts students from over 150 countries around the world, its 12,800 international students making up 31% per cent of the student body. Over half of 苹果淫院 students claim a first language other than English, including approximately 19% of our students who say French is their mother tongue.

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