Josephine Nalbantoglu, PhD
Josephine Nalbantoglu's research interests focus on the molecular genetics of Alzheimer's Disease, on the regulation of gene expression in the nervous system and on gene therapy for brain tumours. In the course of studying the role of amyloid metabolism and deposition in Alzheimer's Disease, her laboratory has generated transgenic mice that express a fragment of the human amyloid precursor protein (APP). These mice show signs of tissue injury and deficits in behaviour that model the changes that occur in Alzheimer's Disease. She is also studying the control of APP gene expression by characterizing important gene regulatory sequences and the proteins binding to them. She is also collaborating with Dr. George Karpati on adenovirus-mediated gene therapy of experimental gliomas and medullablastomas using tumour suppressor and "suicide" genes.
Abstract Sustained improvement of muscle function one year after full-length dystrophin gene transfer into mdx mice by a gutted helper-dependent adenoviral vector. Hum Gene Ther. 2004 Feb;15(2):145-56. PMID: 14975187 [PubMed - in process]
Abstract High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci. 2003 Jul 2;23(13):5789-98. PMID: 12843283 [PubMed - indexed for MEDLINE]
Abstract Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin. Hum Mol Genet. 2003 Jun 1;12(11):1287-99. PMID: 12761044 [PubMed - indexed for MEDLINE]
Abstract Oligodendrocyte injury in multiple sclerosis: a role for p53. J Neurochem. 2003 May;85(3):635-44. PMID: 12694389 [PubMed - indexed for MEDLINE]
Free Full Text Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle. J Virol. 2001 May;75(9):4276-82. PMID: 11287577 [PubMed - indexed for MEDLINE]
Abstract Caspase 8 expression and signaling in Fas injury-resistant human fetal astrocytes. Glia. 2001 Mar 1;33(3):217-24. PMID: 11241739 [PubMed - indexed for MEDLINE]
听Abstract p53 induction by tumor necrosis factor-alpha and involvement of p53 in cell death of human oligodendrocytes. J Neurochem. 1999 Aug;73(2):605-11. PMID: 10428056 [PubMed - indexed for MEDLINE]
Abstract Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein. Hippocampus. 1999;9(3):201-5. PMID: 10401636 [PubMed - indexed for MEDLINE]
Free Full Text Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer. Cancer Res. 1999 May 15;59(10):2384-94. PMID: 10344748 [PubMed - indexed for MEDLINE]
Abstract Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells. Hum Gene Ther. 1999 Apr 10;10(6):1009-19. PMID: 10223734 [PubMed - indexed for MEDLINE]
Free Full Text Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma. Clin Cancer Res. 1999 Mar;5(3):637-42. PMID: 10100717 [PubMed - indexed for MEDLINE]
Abstract Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 1997 May 29;387(6632):500-5. PMID: 9168112 [PubMed - indexed for MEDLINE]
Abstract Transcriptional regulation of amyloid precursor protein during dibutyryl cyclic AMP-induced differentiation of NG108-15 cells. J Neurochem. 1997 Mar;68(3):970-8. PMID: 9048742 [PubMed - indexed for MEDLINE]
