Killam Seminar Series: The Disappearing Act: How Microglia Influence Myelin Health Across the Lifespan
Gr芒ce 脿 la g茅n茅rosit茅 des fiducies Killam, Le Neuro convoque lors d鈥檜ne s茅rie de s茅minaires des conf茅renciers d鈥檈xception dont les travaux passionnent ses chercheurs et ceux de l鈥橴niversit茅 苹果淫院.听
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Veronique Miron, PhD
Chaire John David Eaton, recherche sur la scl茅rose en plaques, Keenan Research Centre for Biomedical Research, St. Michael's Hospital, Canada
Professeure, D茅partement d'immunologie, Universit茅 de Toronto, Canada
贬么迟别: rami.massie [at] mcgill.ca (R)roberta.lapiana [at] mcgill.ca (oberta La Piana)
Abstract:听Myelin is the insulation surrounding axons, which is critical for central nervous system health and function, yet it is damaged in common neurological conditions such as multiple sclerosis (MS) and pathological aging. Although myelin can be regenerated in the form of remyelination, the efficiency of this process decreases with aging and the progression of MS. Our lab has discovered that glial interactions are critical in maintaining myelin health and regulating remyelination post-injury. For instance, we have seen that the absence of microglia is sufficient to initiate spontaneous demyelination. In addition, we have identified surprising mechanisms by which microglia support CNS remyelination. Here, I will present our latest work understanding how microglia influence oligodendrocyte heterogeneity and the dynamics of myelin damage and repair. This has important implications for devising novel therapeutic strategies to support myelin health in aging and disease.
