苹果淫院

厂辫别补办别谤:听 Jesse Brown, Ph.D.

Assistant Professor

Memory and Aging Center

Department of Neurology

University of California San Francisco

叠颈辞:听Jesse is a systems neuroscientist who applies tools from neuroimaging, machine learning, and mathematics. His work focuses on understanding functional and anatomical brain connectivity, and building translational tools to improve the diagnostic and prognostic accuracy of typical and atypical aging trajectories.听

Talk Abstract:听Neurodegenerative diseases appear to progress by spreading through brain networks. I will describe how we determine patient-specific 鈥渆picenters鈥� in patients with frontotemporal dementia and use a connectome-based spreading model to forecast future atrophy. We show that we can accurately predict longitudinal atrophy in most patients and find evidence that degeneration spreads from the epicenter in a nonlinear fashion. This approach raises important questions about the neuroanatomical basis of functional connectivity, which gradients may shed light on. Building on this, I will share a new study where we derive functional activity gradients, describe a number of novel anatomical and dynamic properties of these gradients, and discuss their implications for selective vulnerability to disease.