Dr. Luda Diatchenko
Professor - Departments of Anesthesia, Faculty of Medicine and Health Sciences
Professor - Faculty of Dental Medicine and Oral Health Sciences Faculty
Associate Member - Medicine, Division of Experimental Medicine
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Dr. Diatchenko鈥檚 program aims to identify a mosaic of 鈥減ain genes鈥� and biological pathways contributing to human chronic pain via genome-wide approaches, understand pathophysiology of chronic pain, and find new pain drug targets. Dr. Diatchenko鈥檚 program will allow prediction of new drug efficacy for multiple chronic pain conditions based on individual genetic profiles. It is the world鈥檚 substantial, multidisciplinary effort based on human molecular genetic profiles with potential to transform pain management.
Genome-Wide and Transcriptome-Wide Association Studies on human chronic pain condition.
Ao X, Parisien M, Zidan M, Grant AV, Martinsen AE, Winsvold BS, Diatchenko L. Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain. Pain. 2023 Aug 1;164(8):1841-1851. PMID: 36943258
Diatchenko L, Parisien M, Jahangiri Esfahani S, Mogil JS. Omics approaches to discover pathophysiological pathways contributing to human pain. Pain. 2022 Nov 1;163(Suppl 1):S69-S78. PMID: 35994593
Parisien M, Lima LV, Dagostino C, El-Hachem N, Drury GL, Grant AV, Huising J, Verma V, Meloto CB, Silva JR, Dutra GGS, Markova T, Dang H, Tessier PA, Slade GD, Nackley AG, Ghasemlou N, Mogil JS, Allegri M, Diatchenko L. Acute inflammatory response via neutrophil activation protects against the development of chronic pain. Sci Transl Med. 2022 May 11;14(644):eabj9954. PMID: 35544595
Khoury S, Parisien M, Thompson SJ, Vachon-Presseau E, Roy M, Martinsen AE, Winsvold BS; HUNT All-In Pain; Mundal IP, Zwart JA, Kania A, Mogil JS, Diatchenko L. Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. Brain. 2022 Apr 29;145(3):1111-1123. doi: 10.1093/brain/awab359. PMID: 34788396