/channels/taxonomy/term/18558/all en /channels/channels/news/dr-strauss-publishes-article-journal-cell-biology-cryo-em-structure-complete-and-ligand-saturated-320493 <p>Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor interactions. While biochemistry predicts two distinct insulin binding sites, 1 and 2, recent structural analyses have resolved only site 1. Using a combined approach of cryo-EM and atomistic molecular dynamics simulation, we present the structure of the entire dimeric insulin receptor ectodomain saturated with four insulin molecules.</p> Mon, 17 Feb 2020 19:51:23 +0000 webfull 158833 at /channels /channels/channels/news/new-collaboration-between-reinhardt-group-and-mantovani-group-laval-university-leads-production-288634 <p>One of the tightest bottlenecks in vascular tissue engineering is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, collagen gel-based scaffolds were cellularised with vascular smooth muscle cells (SMCs) and supplemented with human plasma fibronectin (FN), a known master organizer of several extracellular matrix (ECM) fiber systems.</p> Thu, 09 Aug 2018 13:30:50 +0000 webfull 139471 at /channels /channels/channels/news/reinhardt-group-publishes-novel-biological-mechanisms-blood-vessels-plos-biology-288625 <p>Fibronectin is a protein that exists in vertebrates in two distinct forms: one present in the blood and the other in blood vessel walls. In mammals, fibronectin is important for the development of blood vessels before birth, but whether it is continuously required for blood vessel homeostasis from birth to adulthood is unknown. We present important results from three genetically modified mouse models, which show that at least one form of fibronectin is required for the proper function and integrity of blood vessels during this period.</p> Wed, 08 Aug 2018 17:28:10 +0000 webfull 139462 at /channels /channels/channels/event/seminar-dr-soung-hun-roh-287962 <p><a href="http:///anatomy/files/anatomy/seminar_poster_roh.pdf">Molecular Mechanism through Direct Visualization Using Cryo-EM</a></p> Mon, 09 Jul 2018 15:01:51 +0000 webfull 138866 at /channels /channels/channels/event/seminar-dr-ahmad-jomaa-287961 <p><a href="http:///anatomy/files/anatomy/seminar_poster_jomaa.pdf">“Cryo-electron Microscopy Provides Insights into Bacterial and Mammalian Co-translational Targeting of Proteins to the Membrane”</a></p> Mon, 09 Jul 2018 14:58:55 +0000 webfull 138865 at /channels /channels/channels/event/msc-seminar-ian-noel-costas-cancelas-287960 Mon, 09 Jul 2018 14:51:53 +0000 webfull 138864 at /channels